Day 7 Ultrasound

I had another ultrasound yesterday, and things are looking a little better--this time the doctor said she thinks there are 13 or 14 follicles that are big enough. So that is an improvement over the last ultrasound, even though it’s not quite the number I was hoping for.

The egg retrieval is coming up on Sunday. Tonight is my last night of stimulation injections, tomorrow morning is my last Ganirelix, and tomorrow night I do the trigger shot at exactly 10:30 PM. That means that in all, I will have done 8 days of stimulation injections, which feels much shorter than the 11 days I did last time. I am on double the dose of medication this time so I guess it makes sense that it would take less time in total. But I can't believe that this egg freezing cycle is almost done!

I also learned that in addition to the Ovidrel trigger shot, I will also be doing a shot of Lupron at the same time. I am not sure why this is necessary but I will do as the doctor says! I have to pick up the Lupron shot from Walgreens Specialty Pharmacy tomorrow. They mix it up specially and it has a limited shelf life.

In other news, I am definitely feeling my ovaries! Last cycle I thought I felt some heaviness, but I wasn’t entirely sure that it wasn’t my imagination. This time I am positive--I especially feel the one on the left, it is sort of an achy feeling that I especially notice when I am lying down. I hope this means there are a lot of good eggs in there!

First Egg Freezing Cycle: The Trigger Shot

My trigger shot was to be at exactly 9:30 PM on Thursday, November 21, 2013. Earlier that day, I gave myself the last Ganirelix shot.

I had now been on hormones for well over a week. How was I feeling? As it turned out, I was feeling surprisingly normal. I had been concerned that the hormones would affect my mood and that I might experience strange crying jags or temper flares, but that did not happen. Physically I was also feeling pretty good. I was not particularly bloated, and though I thought I could feel my ovaries, I was never quite sure if it was just a figment of my imagination brought on by the suggestion that I should be feeling heaviness in the ovaries. I was however moving differently than usual, in an effort to heed the nurse’s cautions about the risk of ovarian torsion from certain movements. I was supposed to avoid anything that caused bouncing, so I walked more slowly than normal. I had also started taking the elevator up instead of the stairs up to the clinic. I tried to be careful to avoid twisting movements, though I always toss and turn a lot during my sleep so I’m sure I wasn’t able to completely eliminate twisting motions.

The nurse had suggested that I start mixing up my HCG (the trigger shot) at 9:20 PM, to be sure it was ready for 9:30 PM. When I picked up the box, I noticed it said “For intramuscular use only.” I have picked up from other egg freezing blogs and forums that some clinics have their patients do intramuscular shots for the HCG, but at Stanford we are supposed to do a subcutaneous shot. I certainly didn’t have either the training or the needle necessary for an intramuscular shot. I was concerned that I had ended up with the wrong variety of medication. I didn’t know what to do, so I paged the on-call fellow to ask.

When the fellow called back, it was apparent that she hadn’t heard of this exact problem before. I would have loved her to say, “Yes, I know it says “for intramuscular use only” on the box, but it is fine to do the subcutaneous injection.” Instead, she asked me to read her what it said regarding what kind of medicine was in the box, she told me that it sounded like the correct medication, and told me it should be fine to do a subcutaneous injection with it. An answer, but not quite as confidently reassuring as I had hoped for.

Anyway, I set about mixing up the medication and transferring it out of the vial into the injection syringe. I was able to get around two-thirds or three-quarters of the medication into the injection syringe, but I absolutely couldn’t get the last bits out. I remembered the nurse had taught me how to do it after my last ultrasound, but I couldn’t remember what exactly the secret was. I was running way behind now, between paging the on-call fellow and trying to get more medication into the syringe, it was well past 9:30. I finally decided to inject what I could before it got any later. After injecting myself with most of the medication, I set about getting out the last one-quarter to one-third of the medication which was stubbornly stuck in the vial. I held the vial and the syringe at various different angles, desperately trying to get all the medication out. I finally managed to get most of the remainder and gave myself a second injection (thank goodness the clinic had prescribed extra needles, as you need a new needle for each injection). By this time it was well past 10:00. That’s right, I had managed to screw up the timing of this most-important, absolutely-had-to-be-at-9:30 shot.

I emailed the clinic to explain what had happened and then got ready for bed--I would have to leave for my retrieval appointment around 7:00 AM the next day.

First Egg Freezing Cycle: Stimulation Phase, Part 2

I had an ultrasound on my fifth day of injections (actually I’d only done the injections 4 times because the appointment was in the morning and the injections don’t happen until night time).  The nurse asked me if I felt bloated and I said no, I wasn’t feeling anything. I began to worry that it wasn’t working properly since I wasn’t feeling anything. During the ultrasound, the doctor told the nurse (who was taking notes) about the follicles she found: “I see see an 8. Another 8. 3 smaller ones…” The “8” was referring to the size of the follicles, though I have no idea in what units. In all, it sounded like she had only found 9 follicles though I didn’t ask her about it and she didn’t offer a final count. I had been asked to bring my Ganirelix to this appointment in case it was time to start using it. Ganirelix is a drug that keeps you from ovulating during the egg freezing cycle--if you were to ovulate, you would lose all the eggs as they would be released into your body and no longer be available for retrieval. It was not yet time for the Ganirelix. I started to feel pretty discouraged. It seemed like there weren’t many follicles, certainly not the 15 I’d been hoping for, and additionally I wasn’t feeling any side effects of the medication. It wasn’t time for Ganirelix yet, did that mean the stimulation was running behind? I was afraid the stimulation wasn’t working but very well but the doctor rushed out before I had a chance to gather my thoughts and ask her about it.

One interesting thing about Stanford is that unlike most clinics, they don’t give you blood tests during your stimulation phase, only ultrasounds. While I was going through my first egg freezing cycle, I didn’t know that most places give blood tests as well, but I have since picked up that fact from reading other people’s egg freezing blogs and from the Eggsurance.com forums. It sounds like most clinics give blood tests on the same days they give ultrasounds. I guess Stanford does not consider this necessary. Maybe I will ask about the reasoning when I go in for my second egg freezing cycle because it seems sort of strange that Stanford doesn’t take the same measurements as everyone else.

Anyway, after the ultrasound, I went home and got the unused Ganirelix out of my bag to put it back in the fridge. That’s when I noticed that it said to store at room temperature on the package. All my medications had come surrounded by ice packs, so I had assumed they all had to go in the fridge. I checked the other meds and discovered that the HCG, the “trigger shot” I would take 35 hours before the egg retrieval, was also supposed to be stored at room temperature. I started to freak out. This was extremely expensive medication, if I had ruined it by accidentally storing it in the fridge, I didn’t know what I would do! I immediately emailed the clinic to tell them about my mistake and ask if the medication was ok. Thankfully they replied that the fridge would not have hurt the medications.

I  continued on with my injections routine. I did continued to do the Follistim first so that I could lie down immediately after the Menopur in case I got dizzy again. But fortunately I didn’t feel faint again after the Menopur. It was always a pain to mix up and I was always a little scared to give myself the Menopur shot, but at least I wasn’t about to black out anymore (see previous post).

I went in for another ultrasound on Day 7. The doctor again read out the sizes of the follicles. It still didn’t sound like there were very many. I told her I was worried it wasn’t working because I wasn’t experiencing the bloating or feelings of heaviness the nurses asked about. She assured me it was working fine, and that it was a good thing I wasn’t too bloated at this stage. “Don’t worry, you’ll feel it,” she said. It still was not time for Ganirelix.

At my Day 9 ultrasound,  it sounded like there were a few more follicles. Dr. Westphal said my right ovary was not stimulating as well as my left one, and she raised my dose of Follistim from 75 IU to 150 IU.  She also told me that the egg retrieval would not be on the day that was originally planned as I needed to stimulate a bit longer. It was also finally time for the Ganirelix. She told me to give myself the injection right there in the examining room. A nurse brought me a couple of alcohol swabs and then left the room. I was a little flustered. There was no instruction sheet, I couldn’t look up an injection video on the internet, and it was a tiny examining room with no sink so I couldn’t even wash my hands first. I wiped them down with the alcohol swab to try to clean them (you are always supposed to wash your hands before giving yourself an injection). Luckily Ganirelix comes in a pre-filled syringe and doesn’t involve any mixing. The needle looked a little larger than the ones I had become accustomed to. I pinched up some skin and tried to poke the needle in. It wouldn’t go in. I switched to another spot, and still the needle wouldn’t go in. I was really starting to freak out. I finally got lucky on the third or fourth spot I tried; the needle went in and I depressed the plunger on the syringe to give myself the injection. When I was done, some blood came out. I didn’t have a gauze pad or anything so I swabbed it with alcohol and hoped that it wouldn’t become irritated from my jeans. Later on, a bruise developed at that spot. I was not liking this Ganirelix at all.

Now that I was to be on a higher dose of Follistim, I was in danger of running out of medication. Follistim cartridges come in several sizes; mine were 300 IU, each good for 4 days of 75-IU doses. I had 3 cartridges in total so enough for 12 days of stimulation at the original dose, though only 10 days of stimulation had been anticipated. Now I would be moving to a higher dose. Did I need to order more medication? I remembered the nurse had mentioned during the injection training class that the manufacturer over-fills the Follistim cartridges, so we should not throw them away when we’re done in case we need an extra day. I decided to wait on ordering more meds in case the overfill was enough to keep me from buying more.

The next few days I continued with Ganirelix in the morning and Follistim and Menopur at night. I was always afraid of the Ganirelix shot in case I had a repeat of the first time, but luckily there were no more disasters. In order to give myself the Follistim dose on Day 10, I had to use the over-fill from all 3 Follistim cartridges, which involved giving myself 3 separate injections! But it was enough medication.

At my Day 11 ultrasound, it sounded like there were quite a few more follicles. I guess the higher dose was working. Dr. Westphal wanted to stimulate for an additional day, and now I was really going to be out of medication. I had a little bit of Follistim overflow left in the third cartridge, and I was completely out of Menopur. She gave me a prescription to take to the Walgreens Specialty Pharmacy in town for two 75-IU vials of Menopur, and she told me to inject the rest of the Follistim overflow, up to 75 IU. That would take care of my injections for that evening, which would be the last day of of stimulating medications. The following day would be my trigger shot, and the egg retrieval would be on the 14th day of the cycle.

The nurse took me to a little room with a table and two chairs to go over my final instructions prior to the egg retrieval.She gave me a sheet of paper that showed me exactly what time I had to take the “trigger shot” which is HCG. It makes the eggs finish maturing and gets them ready for retrieval. You will ovulate the eggs 40 hours after taking the shot, so the retrieval is set for 35 hours after taking the shot. The timing of this shot is extremely important; if you mess it up, you could basically ruin the entire egg freezing cycle. I had to sign a paper that I understood when I needed to take the shot. The nurse then showed me how to mix up the HCG using a large mixing needle and explained to me how to get all the medication out of the vial and into the syringe. And she gave me a handout about Ovarian Hyperstimulation Syndrome (OHSS). She recommended that I immediately start the suggested OHSS diet, even before the retrieval. The diet involved drinking Gatorade and Pedialyte instead of plain water, and having 3-4 whey protein shakes a day. I was a little annoyed to be told so last-minute since I would have to immediately go out and buy supplies.

I had to wait about an hour at the pharmacy to pick up my medications. And since it was a specialty pharmacy that didn’t have normal drugstore items, I had to go to another drugstore to get the Gatorade, Pedialyte and whey protein powder. That night, I gave myself the last of the stimulation shots. It was nearly over!